ELINKS TEXAS HEALTH ORG SERIES

The major fimbriae are multifunctional adhesins, and mediate adherence to and signaling within bacterial biofilms and host tissues. gingivalis colonization and survival in the host are attributable to a number of persistence factors, including biofilm formation, production of capsule, secretion of proteases, and the presence of major and minor fimbriae. gingivalis: creation of the periodontal pocket, an enlarged sub-gingival space that provides ideal conditions for propagation of this strictly anaerobic, proteolytic microbe. The outcome of tissue destruction is beneficial to P.

gingivalis and other opportunistic pathogens within the oral flora to overcome mucosal defenses and stimulate the inflammatory destruction of the periodontal connective tissues. Inhibition of these host defenses results in a significant increase in total bacterial burden in the sub-gingival sulcus, and enables P. The most important immune dysregulation events appear to be inhibition of IL-8 secretion, subversion of the complement system, and Toll-like receptor antagonism.

gingivalis has multiple strategies for undermining the long-term effectiveness of host defenses, and has been shown in a recent landmark study to be a “keystone” pathogen, able to disrupt host-microbe homeostasis by molecular manipulation of select host protective mechanisms. gingivalis and co-resident commensal microorganisms in close proximity to the non-keratinized junctional epithelium, and in a healthy periodontium, the bacterial burden is restricted by circulating neutrophils and innate immune effectors. Residence within sub-gingival biofilms places P. This bacterium colonizes established multi-species plaque biofilms at the gingival margin and in the sub-gingival sulcus –. Porphyromonas gingivalis is a gram-negative anaerobe that preferentially inhabits the human oral cavity and is a key etiologic agent in the development of periodontal disease. Understanding how these opportunistic bacteria shift from commensal to pathogenic in the host environment will prove pivotal in combating these resourceful organisms in the future. Typically this adaptation process is thought to be driven by spontaneous mutation and horizontal DNA transfer events with the increasing availability of strain-level genome sequences, identification and molecular characterization of these adaptive virulence events is becoming possible.

Further subdividing the opportunistic pathogens, there are a few species that colonize as part of the normal flora, but may evolve within the host habitat to adopt a more overtly pathogenic phenotype. Within these thousands of species are many that are also opportunistic pathogens, capable of causing disease in the event of a failure of host defenses.

ELINKS TEXAS HEALTH ORG SERIES

Video podcast series designed to provide physicians and health care professionals with a brief review of clinical indicators and other key information for accurate and concise documentation in medical records.Complex communities of commensal microorganisms comprise the vast majority of the human body’s natural flora. Health Care Practitioner Human Trafficking TrainingĪccess the Texas Health and Human Services Commission (HHSC) approved course for Human Trafficking education.

View Continuing Education recommended links. Texas Health’s health information exchange (HIE) services offers providers access to medical information (including demographic information, test results, and other clinical documentation) needed to make well-informed decisions for their patients. Texas Health medical staff leadership in partnership with the Texas Health Resources University Accreditation Office is making available a collection of educational activities that have already been approved for credit. Collaboratively leading toward an optimistic future - in any role, at every moment.Īccredited Topics For General Medical Staff Meetings (PDF)

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